Pseudomonas aeruginosa outer membrane vesicles ameliorates lung ischemia-reperfusion injury by regulating the balance of regulatory T cells and Th17 cells through Tim-3 and TLR4/NF-κB pathway.
Bo LiuFengxia DingDing CaoJiang LiuYaping WangChun WuPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)
These results suggest that OMVs preconditioning may ameliorate lung I/R injury by regulating the balance of Tregs and Th17 cells through Tim-3 and TLR4/NF-κB pathway.
Keyphrases
- regulatory t cells
- induced apoptosis
- ischemia reperfusion injury
- signaling pathway
- pseudomonas aeruginosa
- oxidative stress
- cell cycle arrest
- toll like receptor
- nuclear factor
- inflammatory response
- immune response
- lps induced
- pi k akt
- dendritic cells
- endoplasmic reticulum stress
- cystic fibrosis
- escherichia coli
- cell death
- cell proliferation