Engineering CHO cells galactose metabolism to reduce lactate synthesis.

Natalia E JiménezV S MartínezZ P Gerdtzen

Published in: Biotechnology letters (2019)

This cellular engineering strategy, where modifications of key points of alternative carbon sources metabolism lead to an improved metabolism of these sugars, is a starting point towards the generation of new cell lines with reduced lactate synthesis and increased cell growth and productivity.

Keyphrases

induced apoptosis
climate change
cell cycle arrest
oxidative stress
signaling pathway
pi k akt