Pre-clinical results in pig-to-non-human primate islet xenotransplantation using anti-CD40 antibody (2C10R4)-based immunosuppression.
Jun-Seop ShinJong-Min KimByoung-Hoon MinIl Hee YoonHyun Je KimJung-Sik KimYong-Hee KimSeong-Jun KangJiyeon KimHee-Jung KangDong-Gyun LimEung-Soo HwangJongwon HaSang-Joon KimWan Beom ParkChung-Gyu ParkPublished in: Xenotransplantation (2017)
These results showed that anti-CD40 mAb combined with tacrolimus was effective in prolonging porcine islet graft survival, but anti-CD40 mAb was not as effective as anti-CD154 mAb in terms of preventing early islet loss.
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