Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice.
Hae Jin KeeYuhee RyuYoung Mi SeokSin Young ChoiSimei SunGwi Ran KimMyung Ho JeongPublished in: Clinical hypertension (2019)
PCI34051 lowered high blood pressure through modulation of arterial remodeling, vasoconstriction, and inflammation in an angiotensin II-induced hypertension model. We suggest that HDAC8 could be a potential therapeutic target for hypertension.
Keyphrases
- angiotensin ii
- blood pressure
- histone deacetylase
- oxidative stress
- angiotensin converting enzyme
- vascular smooth muscle cells
- hypertensive patients
- heart rate
- diabetic rats
- coronary artery disease
- high glucose
- acute coronary syndrome
- percutaneous coronary intervention
- blood glucose
- single molecule
- st segment elevation myocardial infarction
- type diabetes
- antiplatelet therapy
- atrial fibrillation
- high fat diet induced
- drug induced
- skeletal muscle
- coronary artery bypass grafting
- adipose tissue
- climate change
- insulin resistance