A benchmark study on current GWAS models in admixed populations.

Zikun YangBasilio CiezaDolly Reyes-DumeyerRosa MontesinosMarcio Soto-AñariNilton CustodioGiuseppe Tosto

Published in: Briefings in bioinformatics (2023)

The current study illustrates best practice and limitations for available GWAS tools under the scenario of genetic admixture. Incorporating local ancestry in GWAS analyses boosts power, although careful consideration of complex scenarios (small sample sizes, imbalance case-control ratio, MAF heterogeneity) is needed.

Keyphrases

case control
healthcare
primary care
climate change
gene expression
dna methylation
copy number