Optical Modulation on the Nucleus Accumbens Core in the Alleviation of Neuropathic Pain in Chronic Dorsal Root Ganglion Compression Rat Model.
Elina KcHyeong Cheol MoonSoochong KimHyong Kyu KimSo Yoon WonSang-Hwan HyunYoung Seok ParkPublished in: Neuromodulation : journal of the International Neuromodulation Society (2019)
The NAc core impacts the reward and motivational aspects of chronic neuropathic pain influenced by limbic behaviors to thalamic discharge. Increased thalamic firing activity may result in chronic compressed DRG-induced neuropathic pain, and optogenetic neuromodulation of the NAc can ease chronic pain and thalamic discharge.