Differences in von Willebrand factor function in type 2A von Willebrand disease and left ventricular assist device-induced acquired von Willebrand syndrome.
Shannen J DeconinckClaudia TersteegEls BailleulLeen DelrueNele VandeputteInge PareynNathalie Itzhar-BaikianHans DeckmynSimon F De MeyerMarc VanderheydenKaren VanhoorelbekePublished in: Research and practice in thrombosis and haemostasis (2018)
VWF:CB/VWF:Ag or VWF:RCo/VWF:Ag analysis allows detection of impaired VWF function in VWD type 2A but not always in LVAD-induced aVWS patients. In contrast, VWF multimeric analysis allows detection of the loss of HMW VWF multimers in both groups of patients. Hence, performing VWF multimer analysis is crucial to detect aVWS in LVAD patients.