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Dietary Cholic Acid Exacerbates Liver Fibrosis in NASH Model of Sprague-Dawley Rats Fed a High-Fat and High-Cholesterol Diet.

Mayuko Ichimura-ShimizuShiro WatanabeYuka KashirajimaAmi NagatomoHitomi WadaKoichi TsuneyamaKatsuhisa Omagari
Published in: International journal of molecular sciences (2022)
Adding CA to the HFC diet altered bile acid metabolism and inflammatory response and triggered the development of fibrosis in the rat liver.
Keyphrases
  • liver fibrosis
  • inflammatory response
  • weight loss
  • physical activity
  • lipopolysaccharide induced
  • oxidative stress
  • lps induced
  • toll like receptor