Stereoselective Allylic Alkylations of Amino Ketones and Their Application in the Synthesis of Highly Functionalized Piperidines.
Cynthia PrudelKai HuwigUli KazmaierPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
Chelated ketone enolates are excellent nucleophiles for allylic alkylations. Electron-withdrawing groups on the allyl moiety allow subsequent intramolecular Michael additions giving rise to piperidines with up to five stereogenic centers.