Crosstalk between stressed brain cells: direct and indirect effects of ischemia and aglycemia on microglia.
Monika RabensteinSabine Ulrike VayStefan BlaschkeHelene Luise WalterAnne LadwigGereon Rudolf FinkMaria Adele RuegerMichael SchroeterPublished in: Journal of neuroinflammation (2020)
Data suggest specific and distinct microglia signatures in response to metabolic stress. While metabolic stress directly and indirectly applied to microglia did not mitigate their subsequent response to inflammation, preconditioning with metabolic stress factors such as OGD and aglycemia elicited a decreased inflammatory response to a subsequent inflammation stimulus.
Keyphrases
- oxidative stress
- inflammatory response
- induced apoptosis
- neuropathic pain
- stress induced
- cell cycle arrest
- ischemia reperfusion injury
- cerebral ischemia
- electronic health record
- heat stress
- white matter
- big data
- multiple sclerosis
- genome wide
- resting state
- cell proliferation
- signaling pathway
- machine learning
- endoplasmic reticulum stress
- data analysis
- dna methylation