Life cycle assessment (LCA) models quantifying the environmental aspects of waste management have become an integral part of waste management decision-making over the last two decades and have provided ample knowledge on both environmental benefits and drawbacks in the way we handle waste. Waste management and LCA modelling of waste management systems will soon be challenged by profound changes necessary in our societies and sectors to meet sustainable development goals. Foreseen changes in energy, material, and nutrient provision will directly and indirectly affect waste management in terms of its operation and goals. This study reflects on anticipated changes in society and industrial sectors and how these changes may affect waste management and LCA modelling of waste management systems in terms of waste input, the modelling of technologies and systems and exchanges of energy, materials, and nutrients, as well as how it may affect impact assessment and the interpretation of results. The study provides practical recommendations for LCA modelling of future waste management systems, which will hopefully lead to robust assessments that can support decision-making in an evolving society subject to great changes.