5'-Ectonucleotidase CD73/NT5E supports EGFR-mediated invasion of HPV-negative head and neck carcinoma cells.

Enxian ShiZhengquan WuBirnur Sinem KaraoglanSabina Schwenk-ZiegerGisela KranzNilofer Abdul RazakChristoph A ReichelMartin CanisPhilipp BaumeisterReinhard ZeidlerOlivier Gires

Published in: Journal of biomedical science (2023)

In sum, CD73 is an effector of EGF/EGFR-mediated local invasion and a potential therapeutic target and candidate predictive marker for advanced HPV-negative HNSCC.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
cell migration
tyrosine kinase
high grade
nk cells
dendritic cells
growth factor
cervical cancer screening