Genetic determinants of the humoral immune response in MS.

Christiane GasperiTill F M AndlauerAna KeatingBenjamin KnierAna KleinVerena PernpeintnerPeter LichtnerRalf GoldFrauke ZippFlorian Then BerghMartin StangelHayrettin TumaniBrigitte WildemannHeinz WiendlAntonios BayasTania KümpfelUwe K ZettlRalf A LinkerUlf ZiemannMatthias KnopClemens WarnkeManuel A FrieseFriedemann PaulBjörn TackenbergAchim BertheleBernhard Hemmer

Published in: Neurology(R) neuroimmunology & neuroinflammation (2020)

Although some HLA alleles seem to primarily drive the extent of humoral immune responses in the CNS by increasing CSF B cells and plasmablasts, genetic variants at the immunoglobulin heavy chain constant locus might regulate intrathecal immunoglobulins levels via different mechanisms.

Keyphrases

immune response
mass spectrometry
dendritic cells
multiple sclerosis
toll like receptor
ms ms
blood brain barrier
genome wide
gene expression
inflammatory response