Plasma protein binding of ceftriaxone in critically ill patients: can we predict unbound fractions?

Tim M J EwoldtSoma BahmanyAlan AbdullaAnouk E MullerHenrik EndemanBirgit C P Koch

Published in: The Journal of antimicrobial chemotherapy (2023)

Ceftriaxone protein binding is not concentration related in critically ill patients. Existing models show good ability to predict high concentrations, but low specificity in predicting subtherapeutic concentrations.

Keyphrases

binding protein
protein protein
amino acid
small molecule
transcription factor
drug induced
structural basis