Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart.

Prachi UmbarkarSultan TousifAnand Prakash SinghJoshua C AndersonQinkun ZhangMichelle D TallquistJames WoodgettHind Lal

Published in: Circulation research (2022)

GSK-3α-mediated MEK-ERK activation is a critical profibrotic signaling circuit in the injured heart, which operates independently of the canonical TGF-β1-SMAD3 pathway. Therefore, strategies to inhibit the GSK-3α-MEK-ERK signaling circuit could prevent adverse fibrosis in diseased hearts.

Keyphrases

pi k akt
signaling pathway
cell proliferation
epithelial mesenchymal transition
transforming growth factor
atrial fibrillation
adverse drug