Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis.
Michael WalshPeter A MerkelChen-Au PehWladimir M SzpirtXavier PuechalShouichi FujimotoCarmel M HawleyNader A KhalidiOliver FlossmannRon WaldLouis P GirardAdeera LevinGina GregoriniLorraine HarperWilliam F ClarkChristian PagnouxUlrich SpecksLucy SmythVladimir TesarToshiko Ito-IharaJanak Rashme de ZoysaWojciech SzczeklikLuis Felipe Flores-SuárezSimon CaretteLoïc GuillevinCharles D PuseyAlina L CasianBiljana BrezinaAndrea MazzettiCarol A McAlearElizabeth BroadhurstDonna ReidlingerSamir MehtaNatalie IvesDavid R W Jaynenull nullPublished in: The New England journal of medicine (2020)
Among patients with severe ANCA-associated vasculitis, the use of plasma exchange did not reduce the incidence of death or ESKD. A reduced-dose regimen of glucocorticoids was noninferior to a standard-dose regimen with respect to death or ESKD. (Funded by the U.K. National Institute for Health Research and others; PEXIVAS Current Controlled Trials number, ISRCTN07757494; ClinicalTrials.gov number, NCT00987389.).