PIBF1 suppresses the ATR/CHK1 signaling pathway and promotes proliferation and motility of triple-negative breast cancer cells.
Eun Ji RoSeung-Hee RyuEun-Young ParkJe-Won RyuSang Jun ByunSeung-Ho HeoKang Hyun KimIn-Jeoung BaekByung Ho SonSang-Wook LeePublished in: Breast cancer research and treatment (2020)
For the first time, these findings clarify the role of PIBF1 in regulating ATR/CHK1 signaling pathway and inhibiting the proliferation and migration of TNBC cell lines. These results demonstrate the oncogenic roles of PIBF1 and provide new insights into the function and the molecular mechanism of PIBF1 in malignant TNBC.