A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model.

Taeko KimuraMaiko OnoChie SekiKazuaki SampeiMasafumi ShimojoKazunori KawamuraMing-Rong ZhangNaruhiko SaharaYuhei TakadoMakoto Higuchi

Published in: European journal of nuclear medicine and molecular imaging (2022)

Our imaging platform has enabled the quantification of tau depositions and consequent neuronal loss and is potentially applicable to the evaluation of candidate anti-tau and neuroprotective drugs.

Keyphrases

high resolution
mouse model
cerebrospinal fluid
cerebral ischemia
high throughput
mass spectrometry
brain injury
subarachnoid hemorrhage
blood brain barrier
photodynamic therapy
drug induced