Downregulation of miRNA17-92 cluster marks Vγ9Vδ2 T cells from patients with rheumatoid arthritis.

Giuliana GugginoValentina OrlandoLaura SaievaPiero RuscittiPaola CiprianiMarco Pio La MannaRoberto GiacomelliRiccardo AlessandroGiovanni TrioloFrancesco CicciaFrancesco DieliNadia Caccamo

Published in: Arthritis research & therapy (2018)

Our results provide evidence for a role of miR-106a, miR-19-3p, miR-20a, and miR-21a in the regulation of Vγ9Vδ2 T-cell function in RA patients and suggest the possibility that the miRNA17-92 family and Vγ9Vδ2 T cells contribute to the pathogenesis of RA.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
end stage renal disease
rheumatoid arthritis
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
disease activity
signaling pathway
patient reported outcomes
patient reported