Urinary mitochondrial DNA level as a biomarker of tissue injury in non-diabetic chronic kidney diseases.

Zhongping WeiBonnie Ching-Ha KwanKai Ming ChowPhyllis Mei-Shan ChengCathy Choi-Wan LukKa-Bik LaiPhilip Kam-Tao LiCheuk-Chun Szeto

Published in: BMC nephrology (2018)

Urinary mtDNA levels have no significant association with the rate of renal function decline in non-diabetic CKD, although the levels correlate with baseline renal function, proteinuria, and the severity of histological damage. Urinary mtDNA level may be a surrogate marker of permanent renal damage in non-diabetic CKD.

Keyphrases

mitochondrial dna
copy number
type diabetes
wound healing
chronic kidney disease
oxidative stress
genome wide
dna methylation
gene expression