Edema in childhood nephrotic syndrome: possible genes-hormones interplay.
Hanan El-HalabyAshraf BakrRiham EidHussein Abdelaziz AbdallaAya Ahmed El-HanafyNora ShamekhAmira AdelAhmed El-HusseinyPublished in: Journal, genetic engineering & biotechnology (2022)
During edema, ANP levels are elevated in INS children however this increment is not associated with natriuresis suggesting a blunted renal response to ANP. Polymorphisms of genes regulating ANP levels and receptors don't seem to be implicated in edema formation except for the A1A1 genotype of ScaI polymorphism however, its possible role needs further evaluation.