CILP-1 Is a Biomarker for Backward Failure and Right Ventricular Dysfunction in HFrEF.
Annika WeidenhammerSuriya PrausmüllerClemens PartschGeorg SpinkaBianca LuckerbauerMirella LarchHenrike ArfstenRamy Abdel MawgoudPhilipp E BartkoGeorg GoliaschStefan KastlChristian HengstenbergMartin HülsmannNoemi PavoPublished in: Cells (2023)
CILP-1 correlates with HFrEF severity and may indicate an elevated risk for all-cause mortality, though it is not independent from NT-proBNP. Increased CILP-1 is associated with backward failure and RVD rather than forward failure. Whether CILP-1 release in this context is based on elevated pulmonary pressures or is specific to RVD needs to be further investigated.