DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity.

Yan ZhaoLinjie GuoShuting CaoMo XieHongzhen PengJiang LiShihua LuoLan Ma Lihua Wang

Published in: Chemical communications (Cambridge, England) (2023)

We devise a class of amphiphilic drug complexes by programming hydrophobic drug patterns (HDPs) on DNA frameworks. We investigate the effect of HDPs on cellular uptake efficiency and drug potency. We achieve enhanced cytotoxicity against tumor cells by using an asymmetric HDP.

Keyphrases

circulating tumor
adverse drug
cell free
single molecule
drug induced
ionic liquid
emergency department
aqueous solution