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Efficacy of deep brain stimulation of the subthalamic nucleus versus globus pallidus internus on sensory complaints.

Maria Gabriela S GhilardiAna Carolina P CamposRubens Gisbert CuryRaquel C R MartinezRosana Lima PaganoErich T Fonoff
Published in: NPJ Parkinson's disease (2024)
Pain control after deep brain stimulation (DBS) in Parkinson's disease (PD) remains unclear. Following six months, subthalamic (STN)-DBS reduced sensory complaints related to parkinsonism and bodily discomfort, increasing central beta-endorphin level. Pallidal GPi-DBS decreased bodily discomfort and beta-endorphin levels. Unexplained pain by other conditions and bodily discomfort were negatively correlated with beta-endorphin levels. Thus, DBS regulates central opioids, and prioritizing STN is important for PD patients with significant sensory complications.
Keyphrases
  • deep brain stimulation
  • parkinson disease
  • chronic pain
  • pain management
  • obsessive compulsive disorder
  • neuropathic pain
  • drug induced
  • spinal cord