CX-4945: the protein kinase CK2 inhibitor and anti-cancer drug shows anti-fungal activity.
Maciej MasłykMonika JaneczkoAleksandra MartynaKonrad KubińskiPublished in: Molecular and cellular biochemistry (2017)
CX-4945 is a selective inhibitor of protein kinase CK2 exhibiting clinical significance. Its antitumor properties arise from the abrogation of CK2-mediated pro-survival cellular pathways. The presented data reveal the influence of CX-4945 on the growth of yeast cells showing variable potency against Saccharomyces cerevisiae deletion strains with different contents of CK2 subunits. The catalytic subunit CK2α appears to sensitize yeast to the CX-4945 action. Moreover, the compound suppresses hyphal growth and cell adhesion of Candida albicans, thereby abolishing some hallmarks of invasiveness of the pathogen. It is known that cancer patients are more prone to fungal infections. Our data unveil the dual-activity of CX-4945; when used in anti-cancer therapy, it may simultaneously prevent cancer-associated candidiasis.
Keyphrases
- protein kinase
- candida albicans
- saccharomyces cerevisiae
- biofilm formation
- cancer therapy
- cell adhesion
- electronic health record
- induced apoptosis
- cell wall
- big data
- drug delivery
- signaling pathway
- emergency department
- genome wide
- single cell
- data analysis
- machine learning
- artificial intelligence
- pseudomonas aeruginosa
- deep learning
- cell death
- adverse drug