Suppression of eEF2 phosphorylation alleviates synaptic failure and cognitive deficits in mouse models of Down syndrome.

Xin WangQian YangXueyan ZhouC Dirk KeeneAlexey G RyazanovTao Ma

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Phosphorylation of the translational factor eukaryotic elongation factor 2 (eEF2) is increased in the Down syndrome (DS) brain. Suppression of the eEF2 kinase (eEF2K) alleviates cognitive deficits in DS models. Suppression of eEF2K improves synaptic dysregulation in DS models. Cognitive and synaptic impairments in DS models are rescued by eEF2K inhibitors.

Keyphrases

mouse model
protein kinase
resting state
multiple sclerosis
functional connectivity
cerebral ischemia