Tissue glucocorticoid metabolism in adrenal insufficiency: a prospective study of dual-release hydrocortisone therapy.

Rosemary A Dineen Julie Martin-GraceKhalid Mohamed Saeed AhmedAngela E TaylorFozia ShaheenLina SchifferLorna C GilliganGareth G LaveryIsolda FrizelleAnjuli Gunness Aoife Garrahy Anne Marie Hannon Paal MethlieSverre Husebye EysteinPaul M Stewart Jeremy W TomlinsonJames M HawleyBrian G KeevilMichael W O'ReillyDiarmuid SmithJohn McDermottMarie-Louise HealyAmar AghaAgnieszka PazderskaJames GibneyLucy-Ann BehanChris J ThompsonWiebeke Arlt Mark Sherlock

Published in: The Journal of clinical endocrinology and metabolism (2023)

Using comprehensive in-vivo techniques, we have demonstrated abnormalities in corticosteroid metabolism in patients with primary and secondary AI receiving IR-HC. This dysregulation of pre-receptor glucocorticoid metabolism results in enhanced glucocorticoid activation in adipose tissue, which was ameliorated by treatment with DR-HC.

Keyphrases

adipose tissue
insulin resistance
metabolic syndrome
stem cells
type diabetes
machine learning