Metabolic and behavioral alterations associated with viral vector-mediated toxicity in the paraventricular hypothalamic nucleus.

Rohan SavaniErin ParkNidhi BusannagariYi LuHyook Joon KwonLe Wang Zhiping P Pang

Published in: bioRxiv : the preprint server for biology (2023)

Our findings reveal that delivery of AAV8-hSyn-Cre could lead to cellular toxicity and lesions in the PVN that cause robust metabolic and behavioral impacts. These alterations can complicate the interpretation of AAV-Cre-mediated gene knockout and highlight the need for rigorous controls.

Keyphrases

genome wide
oxidative stress
gene therapy
sars cov
single cell
dna methylation