Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection.
Chetan SeshadriNafiseh SedaghatMonica CampoGlenna PetersonRichard D WellsGregory S OlsonDavid R ShermanCatherine M SteinHarriet Mayanja-KizzaAli ShojaieW Henry BoomThomas R Hawnnull nullPublished in: PloS one (2017)
Monocytes from individuals who appear to resist clinical M.tb infection differentially activate pathways controlled by histone deacetylase in response to in-vitro M.tb infection when compared to those who are susceptible and develop latent tuberculosis. These data identify a potential cellular mechanism underlying the clinical phenomenon of resistance to M.tb infection despite known exposure to an infectious contact.