Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection.

Chetan SeshadriNafiseh SedaghatMonica CampoGlenna PetersonRichard D WellsGregory S OlsonDavid R ShermanCatherine M SteinHarriet Mayanja-KizzaAli ShojaieW Henry BoomThomas R Hawnnull null

Published in: PloS one (2017)

Monocytes from individuals who appear to resist clinical M.tb infection differentially activate pathways controlled by histone deacetylase in response to in-vitro M.tb infection when compared to those who are susceptible and develop latent tuberculosis. These data identify a potential cellular mechanism underlying the clinical phenomenon of resistance to M.tb infection despite known exposure to an infectious contact.

Keyphrases

mycobacterium tuberculosis
gene expression
dendritic cells
emergency department
immune response
electronic health record
machine learning
big data
peripheral blood
drug induced