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Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection.

Chetan SeshadriNafiseh SedaghatMonica CampoGlenna PetersonRichard D WellsGregory S OlsonDavid R ShermanCatherine M SteinHarriet Mayanja-KizzaAli ShojaieW Henry BoomThomas R Hawnnull null
Published in: PloS one (2017)
Monocytes from individuals who appear to resist clinical M.tb infection differentially activate pathways controlled by histone deacetylase in response to in-vitro M.tb infection when compared to those who are susceptible and develop latent tuberculosis. These data identify a potential cellular mechanism underlying the clinical phenomenon of resistance to M.tb infection despite known exposure to an infectious contact.
Keyphrases
  • mycobacterium tuberculosis
  • gene expression
  • dendritic cells
  • emergency department
  • immune response
  • electronic health record
  • machine learning
  • big data
  • peripheral blood
  • drug induced