α-hemolysin of Staphylococcus aureus impairs thrombus formation.
Kristin JahnStefan HandtkeRaghavendra PalankarThomas P KohlerJan WescheMartina WolffJanina BayerChristiane WolzAndreas GreinacherSven HammerschmidtPublished in: Journal of thrombosis and haemostasis : JTH (2022)
Our findings might be of clinical relevance for S. aureus induced endocarditis. Stabilizing the aortic-valve thrombi by inhibiting Hla-induced impairment of platelets might reduce the risk for septic (micro-)embolization.
Keyphrases
- aortic valve
- staphylococcus aureus
- high glucose
- transcatheter aortic valve replacement
- diabetic rats
- transcatheter aortic valve implantation
- aortic valve replacement
- aortic stenosis
- acute kidney injury
- drug induced
- signaling pathway
- heart failure
- endothelial cells
- oxidative stress
- ejection fraction
- methicillin resistant staphylococcus aureus
- candida albicans