Glutamate levels across deep brain structures in patients with a psychotic disorder and its relation to cognitive functioning.

Tommy A A BroedersAlex A BhogalLisan M MorsinkhofMenno M SchoonheimChristian H RöderMirte EdensDennis Wj KlompJannie P WijnenChristiaan H Vinkers

Published in: Journal of psychopharmacology (Oxford, England) (2022)

We find reduced glutamate levels across DGM structures including the caudate and putamen in patients with a psychotic disorder that are linked to psychomotor speed. Despite limitations concerning age differences, these results underscore the potential role of detailed in vivo glutamate assessments to understand cognitive deficits in psychotic disorders.

Keyphrases

bipolar disorder
high resolution
resting state
functional connectivity
mass spectrometry
risk assessment
climate change