REM sleep atonia loss distinguishes synucleinopathy in older adults with cognitive impairment.
Stuart J McCarterGrace M TabatabaiHo-Yann JongDavid J SandnessPaul C TimmKatie L JohnsonAllison R McCarterRodolfo SavicaPrashanthi VemuriMary M MachuldaKejal KantarciMichelle M MielkeBradley F BoeveMichael H SilberErik K St LouisPublished in: Neurology (2019)
This study provides Class III evidence that quantitative RSWA analysis is useful for distinguishing cognitive impairment phenotypes. Further studies with pathologic confirmation of dementia diagnoses are needed to confirm the diagnostic utility of RSWA in dementia.