Long-Term Intake of Proton-Pump Inhibitors Could Be Associated with an Increased Incidence of Liver Cancer in Women.
Sven Heiko LoosenMarkus Sebastian JördensCatherine LeyhTom LueddeChristoph RoderburgKarel KostevPublished in: Cancers (2024)
Our data suggest that long-term PPI intake in women as well as in patients < 60 years might be associated with an increased risk of liver cancer. These findings support current efforts to reduce the inappropriate use of PPIs in routine clinical practice and to link PPI prescribing to a clear medical indication.
Keyphrases
- clinical practice
- polycystic ovary syndrome
- end stage renal disease
- primary care
- ejection fraction
- newly diagnosed
- chronic kidney disease
- healthcare
- pregnancy outcomes
- prognostic factors
- weight gain
- patient reported outcomes
- cervical cancer screening
- electronic health record
- type diabetes
- emergency department
- metabolic syndrome
- body mass index
- machine learning
- insulin resistance
- small molecule
- adverse drug
- data analysis
- drug induced