Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease.
Tina RönnAlexander PerfilyevJosefine JönssonKarl-Fredrik ErikssonSine W JørgensenCharlotte BrønsLinn GillbergAllan VaagElisabet Stener-VictorinCharlotte LingPublished in: Human molecular genetics (2023)
This study identified novel epigenetic alterations in adipose tissue associated with circulating lipids. Identified epigenetic changes seem to mediate effects of triglycerides on insulin resistance.
Keyphrases
- adipose tissue
- dna methylation
- insulin resistance
- genome wide
- gene expression
- high fat diet
- endothelial cells
- polycystic ovary syndrome
- metabolic syndrome
- skeletal muscle
- type diabetes
- high density
- high fat diet induced
- copy number
- induced pluripotent stem cells
- genome wide identification
- bioinformatics analysis
- weight loss