Association of Regulatory Genetic Variants for Protein Kinase Cα with Mortality and Drug Efficacy in Patients with Heart Failure.

Jasmine A LuzumChristopher TingEdward L PetersonHongsheng GuiTyler ShuggL Keoki WilliamsLiang LiWolfgang SadeeDanxin WangDavid E Lanfear

Published in: Cardiovascular drugs and therapy (2020)

A recently discovered cardiac-specific regulatory variant for PRKCA (rs9909004) was independently associated with a decreased risk for all-cause mortality in patients with HF. The variant did not interact with mortality benefit associated with cornerstone HF pharmacotherapies.

Keyphrases

cardiovascular events
protein kinase
transcription factor
risk factors
left ventricular
acute heart failure
type diabetes
heart failure
emergency department
adverse drug
drug induced
electronic health record