KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway.

Hongyuan XuRan HuoHao LiYuming JiaoJiancong WengJie WangZihan YanJunze ZhangShaozhi ZhaoQiheng HeYingfan SunShuo WangYong Cao

Published in: Stroke and vascular neurology (2022)

mutant induces the EndMT by activating the ERK-TGF-β/BMP-SMAD4 signalling pathway and that lovastatin inhibits the EndMT by suppressing TGF-β/BMP pathway activation and SMAD4 acetylation.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
mesenchymal stem cells
signaling pathway
bone regeneration
wild type
cell proliferation
high glucose
white matter
diabetic rats
bone marrow
oxidative stress
multiple sclerosis
brain injury