The alkaloids of Corydalis hendersonii Hemsl. contribute to the cardioprotective effect against ischemic injury in mice by attenuating cardiomyocyte apoptosis via p38 MAPK signaling pathway.
Fuxing GeXiaoli GaoXiaochun ZhouJunjun LiXiaojing MaMeiwen HuangSana WukenPengfei TuChao AnXingyun ChaiPublished in: Chinese medicine (2023)
RAF improves cardiac function by inhibiting apoptosis via p38 MAPK signaling pathway, and RAF contributes to the effect against myocardial ischemic injury of TE in mice, which provides a substantial reference for the clinical application against ischemia heart disease and quality control of CH.
Keyphrases
- signaling pathway
- quality control
- pi k akt
- cell cycle arrest
- oxidative stress
- endoplasmic reticulum stress
- epithelial mesenchymal transition
- cell death
- induced apoptosis
- high fat diet induced
- ischemia reperfusion injury
- left ventricular
- pulmonary hypertension
- type diabetes
- heart failure
- metabolic syndrome
- skeletal muscle
- angiotensin ii
- endothelial cells