Association of Apolipoprotein E ɛ4 Allele with Enlarged Perivascular Spaces.
Adlin PinheiroSerkalem DemissieAshlea ScrutonAndreas CharidimouPedram ParvaCharles DeCarliSudha SeshadriJosé Rafael RomeroPublished in: Annals of neurology (2022)
The APOE-ɛ4 allele plays a modest role in the burden of enlarged perivascular spaces in the centrum semiovale. Further studies are needed to clarify the underlying small vessel disease type in community-dwelling individuals with predominant centrum semiovale enlarged perivascular spaces, which may be hypertensive angiopathy in our sample. ANN NEUROL 2022;92:23-31.