Recombinant CTRP9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice.
Lianhua ZhaoShengpan ChenPrativa SherchanYan DingWei ZhaoZaiyu GuoJing YuJiping TangArne P NeyrinckPublished in: Journal of neuroinflammation (2018)
Our findings demonstrated that administration of rCTRP9 attenuated neuroinflammation through AdipoR1/AMPK/NFκB signaling pathway after ICH in mice, thereby reducing brain edema and improving neurological function after experimental ICH in mice. Therefore, CTRP9 may provide a potential therapeutic strategy to alleviate neuroinflammation in ICH patients.
Keyphrases
- signaling pathway
- lps induced
- cerebral ischemia
- high fat diet induced
- lipopolysaccharide induced
- traumatic brain injury
- end stage renal disease
- pi k akt
- cognitive impairment
- newly diagnosed
- inflammatory response
- ejection fraction
- brain injury
- chronic kidney disease
- insulin resistance
- metabolic syndrome
- epithelial mesenchymal transition
- wild type
- prognostic factors
- peritoneal dialysis
- subarachnoid hemorrhage
- patient reported outcomes
- white matter
- induced apoptosis
- adipose tissue
- cell proliferation
- protein kinase
- multiple sclerosis
- resting state
- binding protein
- toll like receptor