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Polygenic risk-tailored screening for prostate cancer: A benefit-harm and cost-effectiveness modelling study.

Thomas CallenderMark EmbertonStephen MorrisRosalind A EelesZSofia Kote-JaraiPaul David Peter PharoahNora Pashayan
Published in: PLoS medicine (2019)
Based on the results of this modelling study, offering screening to men at higher risk could potentially reduce overdiagnosis and improve the benefit-harm tradeoff and the cost-effectiveness of a prostate cancer screening program. The optimal threshold will depend on societal judgements of the appropriate balance of benefits-harms and cost-effectiveness.
Keyphrases
  • prostate cancer
  • radical prostatectomy
  • quality improvement
  • middle aged