Visual detection of single-nucleotide polymorphisms and DNA methyltransferase based on cation-exchange of CuS nanoparticles and click chemistry of functionalized gold nanoparticles.
X R ZhangShu-Sheng ZhangF T ChenY LiS S ZhangPublished in: Chemical communications (Cambridge, England) (2018)
A novel biosensor was developed based on the cation-exchange of CuS nanoparticles (NPs) and Cu(i)-based click chemistry of functionalized gold nanoparticles (AuNPs). As a proof-of-principle, novel applications of this method as a versatile biosensor for single-nucleotide polymorphisms (SNPs) and DNA methyltransferase (MTase) were presented.
Keyphrases
- gold nanoparticles
- circulating tumor
- quantum dots
- cell free
- single molecule
- ionic liquid
- reduced graphene oxide
- label free
- drug discovery
- molecularly imprinted
- genome wide
- nucleic acid
- loop mediated isothermal amplification
- sensitive detection
- walled carbon nanotubes
- gene expression
- dna methylation
- genome wide association