Cancer is a growing worldwide health problem with the most broadly studied treatments, in which immunotherapy has made notable advancements in recent years. However, innumerable patients have presented a poor response to immunotherapy and simultaneously experienced immune-related adverse events, with failed therapeutic results and increased mortality rates. Consequently, it is crucial to develop alternate tactics to boost therapeutic effects without producing negative side effects. Ultrasound is considered to possess significant therapeutic potential in the antitumor field because of its inherent characteristics, including cavitation, pyrolysis, and sonoporation. Herein, this timely review presents the comprehensive and systematic research progress of ultrasound-enhanced cancer immunotherapy, focusing on the various ultrasound-related mechanisms and strategies. Moreover, this review summarizes the design and application of current sonosensitizers based on sonodynamic therapy, with an attempt to provide guidance on new directions for future cancer therapy.
Keyphrases
- magnetic resonance imaging
- cancer therapy
- end stage renal disease
- ultrasound guided
- public health
- healthcare
- chronic kidney disease
- newly diagnosed
- mental health
- cardiovascular disease
- stem cells
- prognostic factors
- papillary thyroid
- drug delivery
- cardiovascular events
- squamous cell carcinoma
- risk assessment
- computed tomography
- type diabetes
- peritoneal dialysis
- coronary artery disease
- bone marrow
- health information
- climate change
- squamous cell
- current status
- lymph node metastasis
- cell therapy
- smoking cessation