Diagnostic Accuracy of Highest-Grade or Predominant Histological Differentiation of T1 Colorectal Cancer in Predicting Lymph Node Metastasis: A Systematic Review and Meta-Analysis.
Jun WatanabeKatsuro IchimasaYuki KataokaShoko MiyaharaAtsushi MikiKhay Guan YeohShigeo KawaiFernando Martínez de JuanIsidro MachadoKazuhiko KotaniNaohiro SataPublished in: Clinical and translational gastroenterology (2024)
Highest-grade differentiation may reduce the risk of misclassifying cases with LNM as negative, whereas predominant differentiation may prevent unnecessary surgeries. Further studies should examine differentiation classification using other predictive factors.