Sex- and time-specific associations of obesity with glycaemic traits: A two-step multivariate Mendelian randomization study.

Ye TianGuochen MaJing ZiYifan HuYaxian ZengHaoqi LiHang LuoShufang ShanJingyuan XiongGuo Cheng

Published in: Diabetes, obesity & metabolism (2024)

Our findings provide evidence for causal and independent effects of sex- and time-specific anthropometric traits on glycaemic variables, and highlight the importance of considering multiple obesity exposures at different time points in the life course.

Keyphrases

type diabetes
insulin resistance
metabolic syndrome
weight loss
high fat diet induced
weight gain
genome wide
body composition
adipose tissue
gene expression
skeletal muscle
physical activity
body mass index
data analysis