Effect of transient obstructive cholestasis on liver histology: a cross-sectional study.

Thalita Mendes Mitsunaga Laísa Simakawa Jimenez Pedro França da Costa Soares Martinho Antônio Gestic Martinho Antonio Gestic Felipe David Mendonça Chaim Francisco Callejas-Neto Elinton Adami Chaim Everton Cazzo

Published in: Sao Paulo medical journal = Revista paulista de medicina (2021)

Transient cholestasis was associated with significant histopathological changes, even after its resolution. Longer duration of obstruction correlated with greater severity of histopathological changes, especially cholestasis and ductular proliferation. This emphasizes the need for early treatment of obstructive cholestasis.

Keyphrases

drug induced
physical activity
signaling pathway
risk factors
combination therapy
blood brain barrier