Mass spectrometry-based analysis on the impact of whole blood donation on the global plasma proteome.
Iris C KreftArie J HoogendijkCarmen van der ZwaanFloris P J van AlphenMariette Boon-SpijkerFemmeke J PrinszeAlexander B MeijerDirk de KorteKatja van den HurkMaartje van den BiggelaarPublished in: Transfusion (2023)
Overall, our proteomic approach shows that whole blood donation has a limited impact on the plasma proteins measured. Our findings suggest that plasma profiling can be successfully employed to consistently detect proteins and protein complexes that reflect the functionality and integrity of platelets, red blood cells, and immune cells in blood donors and thus highlights its potential use for donor health monitoring.