Impaired synaptic plasticity and decreased excitability of hippocampal glutamatergic neurons mediated by BDNF downregulation contribute to cognitive dysfunction in mice induced by repeated neonatal exposure to ketamine.

Jie WanLinhui MaXinhao JiaoWei DongJiatao LinYongkang QiuWeifeng WuQiang LiuChen ChenHe HuangShuai LiHui ZhengYu-Qing Wu

Published in: CNS neuroscience & therapeutics (2024)

BDNF downregulation mediates synaptic plasticity and excitability damage, leading to cognitive impairments in adulthood following repeated ketamine exposure during the neonatal period.

Keyphrases

cell proliferation
transcranial direct current stimulation
signaling pathway
pain management
stress induced
spinal cord
oxidative stress
depressive symptoms
high fat diet induced
cerebral ischemia
early life
adipose tissue
subarachnoid hemorrhage