A Mendelian Randomization Analysis of 55 Genetically Predicted Metabolic Traits with Breast Cancer Survival Outcomes in the Pathways Study.
Peter N FioricaHaiyang ShengQianqian ZhuJanise M RohCecile A LaurentIsaac J ErgasJennifer DelmericoMarilyn L KwanLawrence H KushiChristine B AmbrosoneSong YaoPublished in: Cancer research communications (2023)
To our knowledge, this is the largest study of PGS for metabolic traits with breast cancer prognosis. The findings revealed significant associations of PGS for cardiovascular disease, hypertension, and cystatin C levels with several breast cancer survival outcomes. These findings implicate an underappreciated role of metabolic traits in breast cancer prognosis that would warrant further exploration.