Differences in Brain Activity Between Dopa-Responsive and -Unresponsive Pain in Parkinson's Disease.

Jin Hua ZhengWen Hua SunJian Jun MaZhi Dong WangQing Qing ChangLin Rui DongXiao Xue ShiMing Jian Li

Published in: Pain and therapy (2022)

Regional neural activity and functional connectivity in the brain differ substantially among Parkinson's patients with dopa-unresponsive pain, dopa-responsive pain or no pain. Our results suggest that dopa-responsive and -unresponsive pain may arise through different mechanisms, which may help guide the development of targeted therapies.

Keyphrases

chronic pain
pain management
functional connectivity
neuropathic pain
resting state
cancer therapy
spinal cord injury
multiple sclerosis
drug delivery
postoperative pain