Airway and blood monocyte transcriptomic profiling reveals an antiviral phenotype in RSV-infected infants with severe disease.

K ChappinS B BestemanM P HennusJ G WildenbeestM MokryLouis J BontM van der VlistJ J A Calisnull null

Published in: The Journal of infectious diseases (2023)

We found that the RSV-induced interferon response extends from the airways to the peripheral blood. Moreover, RSV induces a migration-promoting transcriptional program in monocytes. Unravelling the monocytic response and its role in the immune response to RSV infection could help the development of therapeutics to prevent severe disease.

Keyphrases

peripheral blood
respiratory syncytial virus
respiratory tract
dendritic cells
single cell
early onset
drug induced
cystic fibrosis
high glucose
quality improvement
transcription factor
endothelial cells
small molecule
rna seq
immune response
diabetic rats
oxidative stress
heat shock